Evaluation of efficacy and safety of Clarina cream in newly diagnosed and previously treated cases of acne vulgaris

Tretinoin is the most effective available topical comedolytic agent, but topical application may lead to erythema, peeling and burning of the skin. During the past few decades many reports have documented an emergence of antibiotic resistance by Propionibacterium acnes during treatment of acne. Furthermore, systemic antimicrobials used in the treatment of acne have been causally associated with various shortand long-term adverse effects. Clarina cream, a polyherbal formulation containing extracts of Aloe barbadensis, Prunus amygdalus, Alternanthera sessilis, and Rubia cordifolia, was found to be beneficial in topical treatment of acne vulgaris. The present study was planned to evaluate the efficacy and safety of Clarina cream in management of acne vulgaris.